Exercise triggers the release of a potent protein, cardiotrophin-like cytokine factor 1 (CLCF1), that may reverse age-related muscle and bone decline. South Korean researchers discovered that CLCF1 surges during workouts, especially resistance training, offering potential anti-aging benefits. The protein’s restoration to youthful levels through exercise could combat age-related muscle loss and osteoporosis. CLCF1, part of the myokines family, targets muscle and bone simultaneously, addressing weakening tissues that lead to frailty. While the study primarily involved mice, human blood samples showed age-related CLCF1 decline, reversed by resistance training and high-intensity exercise. However, the human studies had limitations, necessitating further investigation. This research, published in Nature Communications, highlights the importance of physical activity for healthy aging. (Studyfinds)